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La variante Lambda COVID está en California: 5 cosas que debe saber

POR BARBARA FEDER OSTROV, CalMatters 13 DE AGOSTO DE 2021 ACTUALIZADO EL 16 DE AGOSTO DE 2021

 

Si y si. Desde septiembre de 2020, la variante lambda ha representado 152 casos de COVID-19 secuenciados genéticamente en California, según el Departamento de Salud Pública del estado. El primer caso se encontró en septiembre, con otros 10 en marzo, 88 en abril, 43 en mayo, ocho en junio y, más recientemente, dos casos en julio.

 

La agencia estatal se negó a identificar los condados donde ocurrieron los casos.

Los laboratorios comerciales y gubernamentales prueban las variantes secuenciando el genoma del coronavirus que causó un caso particular de COVID-19 y buscando mutaciones y cambios en la proteína de pico característica del virus.

 

Aún así, no todos los casos de COVID-19 se secuencian genéticamente para determinar si fue causado por una variante, por lo que la cantidad de casos causados ​​por lambda podría ser mayor. A nivel nacional, solo se secuencian alrededor de 15 de cada 1,000 casos.

 

Se han reportado al menos 1.311 casos de lambda secuenciados en al menos 40 estados desde el inicio de la pandemia, con 18 casos identificados en las últimas cuatro semanas, según la base de datos pública de secuencias genéticas de virus GISAID. Solo una décima parte del 1 por ciento de los casos que se secuencian genéticamente involucran a lambda, según GISAID.

 

¿Cómo se compara la variante lambda con otras variantes conocidas?

Los científicos creen que lambda es menos infeccioso que la variante delta, pero más infeccioso que el virus original “de tipo salvaje”, al menos en las pruebas de laboratorio.

Pero aún no saben cómo afectará el diferente perfil genético de lambda a la transmisión comunitaria, la gravedad de los síntomas o la resistencia a las vacunas en todo el mundo. Están surgiendo algunas pistas tempranas.

 

Los investigadores chilenos probaron lambda contra anticuerpos de trabajadores de la salud que recibieron la vacuna Sinovac de fabricación china, y encontraron que la vacuna no funcionó tan bien como lo hizo con el virus original.

 

Además, los investigadores de la Universidad de Nueva York probaron lambda contra las vacunas autorizadas en los Estados Unidos y encontraron que la vacuna de una dosis de Johnson and Johnson era menos efectiva contra ella y la variante delta en comparación con las vacunas de dos dosis de Pfizer y Moderna.

 

Una vez más, estos son estudios en tubos de ensayo que no han sido revisados ​​por pares, advierten los científicos.

 

El hecho de que las vacunas parezcan menos efectivas cuando se comparan con lambda en un tubo de ensayo no significa que no protejan contra enfermedades graves, dijo el Dr. Peter Chin-Hong, especialista en enfermedades infecciosas de la Universidad de California en San Francisco. Casi todas las hospitalizaciones y muertes en California y en todo el país han ocurrido en personas no vacunadas.

 

¿Necesito preocuparme?

No por ahora, dijo Chin-Hong. Lambda ha existido durante meses, pero no se ha afianzado en California y otros estados, por lo que debería ser tranquilizador, dijo.

Hasta ahora, la variante delta ha desplazado definitivamente a otras variantes en todo el país. Ahora representa al menos el 86% de los casos de COVID-19 secuenciados de California y más del 94% de los casos de EE. UU.

 

“Delta es agresivo en todo el mundo y el lambda realmente no ha despegado”, dijo Chin-Hong. “Al final del día, es la supervivencia del más apto”.

La cobertura, traducción y distribución de CalMatters COVID-19 cuenta con el apoyo de generosas subvenciones de Blue Shield of California Foundation, Penner Family Foundation y California Health Care Foundation.

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